Queen Masenate Mohato Seeiso, born Anna Karabo Motšoeneng on June 2, 1976, is the Queen of Lesotho as the wife of King Letsie III of Lesotho. She holds the significant distinction of being the first commoner in modern history to marry into the royal family of Lesotho. Throughout her life, Queen Masenate has played a vital role in promoting charitable causes and raising awareness about HIV/AIDS.